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John Resig
4.18
Description:
Three difficult problems that have been especially challenging, as of late: How do you tackle the problem of running JavaScript tests against dozens of browsers on multiple platforms? What are the best ways of analyzing JavaScript performance, without yielding to incorrect, browser-reported, numbers? And how do you stop cheaters from cracking your JavaScript-based games?

I didn't attend, but from the videos of the talk on vimeo, it was excellent!